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Page 1
Genetics and cytogenetics of Waldenstrom's macroglobulinemia.
Schop RF, Fonseca R. Schop RF, et al. Semin Oncol. 2003 Apr;30(2):142-5. doi: 10.1053/sonc.2003.50075. Semin Oncol. 2003. PMID: 12720124
Translocations involving the immunoglobulin heavy chain locus (IgH) translocations could not be detected in any case, and a molecular analysis showed that the IgH locus switch mu retained its germline configuration. ...The only recurrent chromosome abnormality found …
Translocations involving the immunoglobulin heavy chain locus (IgH) translocations could not be detected in any case, and a molecular …
MLL1 inhibition reduces IgM levels in Waldenström macroglobulinemia.
Karbalivand M, Almada LL, Ansell SM, Fernandez-Zapico ME, Elsawa SF. Karbalivand M, et al. Leuk Res. 2022 May;116:106841. doi: 10.1016/j.leukres.2022.106841. Epub 2022 Apr 19. Leuk Res. 2022. PMID: 35462170
Further analysis identified MLL1 binding at multiple sites in the 5' Emu enhancer of the immunoglobulin heavy (IGH) chain. We found increased histone 3 lysine 4 trimethylation (H3K4me3) enrichment at multiple MLL1 binding sites upon LPS stimulation, a known inducer of IgM. …
Further analysis identified MLL1 binding at multiple sites in the 5' Emu enhancer of the immunoglobulin heavy (IGH) chain. We found i …
Immunophenotypic and cytogenetic comparison of Waldenstrom's macroglobulinemia with splenic marginal zone lymphoma.
Ocio EM, Hernandez JM, Mateo G, Sanchez ML, Gonzalez B, Vidriales B, Gutierrez NC, Orfao A, San Miguel JF. Ocio EM, et al. Clin Lymphoma. 2005 Mar;5(4):241-5. doi: 10.3816/clm.2005.n.007. Clin Lymphoma. 2005. PMID: 15794856
The principal molecular abnormality in WM is 6q deletion (30% in our experience), whereas in SMZL the most common abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10%). Interestingly, the incidence of IgH rearrangement was low in WM (12%) and SMZL (10%). Im …
The principal molecular abnormality in WM is 6q deletion (30% in our experience), whereas in SMZL the most common abnormalities are loss of …
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Nguyen-Khac F, Lambert J, Chapiro E, Grelier A, Mould S, Barin C, Daudignon A, Gachard N, Struski S, Henry C, Penther D, Mossafa H, Andrieux J, Eclache V, Bilhou-Nabera C, Luquet I, Terre C, Baranger L, Mugneret F, Chiesa J, Mozziconacci MJ, Callet-Bauchu E, Veronese L, Blons H, Owen R, Lejeune J, Chevret S, Merle-Beral H, Leblondon V; Groupe Français d'Etude de la Leucémie Lymphoïde Chronique et Maladie de Waldenström (GFCLL/MW); Groupe Ouest-Est d’étude des Leucémie Aiguës et Autres Maladies du Sang (GOELAMS); Groupe d’Etude des Lymphomes de l’Adulte (GELA). Nguyen-Khac F, et al. Haematologica. 2013 Apr;98(4):649-54. doi: 10.3324/haematol.2012.070458. Epub 2012 Oct 12. Haematologica. 2013. PMID: 23065509 Free PMC article. Clinical Trial.
There was a significant association between trisomy of chromosome 4 and trisomy of chromosome 18. Translocations involving the IGH genes were rare (<5%). Deletion of 6q and 11q, and trisomy 4, were significantly associated with adverse clinical and biological parameters …
There was a significant association between trisomy of chromosome 4 and trisomy of chromosome 18. Translocations involving the IGH ge …
Landscape of immunoglobulin heavy chain gene repertoire and its clinical relevance to LPL/WM.
Wang J, Yan Y, Xiong W, Song G, Wang Y, Zhao J, Jia Y, Li C, Yu Z, Yu Y, Chen J, Jiao Y, Wang T, Lyu R, Li Q, Ma Y, Liu W, Zou D, An G, Sun Q, Wang H, Xiao Z, Wang J, Qiu L, Yi S. Wang J, et al. Blood Adv. 2022 Jul 12;6(13):4049-4059. doi: 10.1182/bloodadvances.2022007279. Blood Adv. 2022. PMID: 35537114 Free PMC article.
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) is a heterogeneous disease in which the role of immunoglobulin heavy-chain genes (IGHs) remains unknown. To determine the clinical relevance of the IGH repertoire in patients with LPL/WM, we performed immuno …
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) is a heterogeneous disease in which the role of immunoglobulin heavy-chain …
Rarity of IgH translocations in Waldenstrom macroglobulinemia.
Ackroyd S, O'Connor SJ, Owen RG. Ackroyd S, et al. Cancer Genet Cytogenet. 2005 Nov;163(1):77-80. doi: 10.1016/j.cancergencyto.2005.04.009. Cancer Genet Cytogenet. 2005. PMID: 16271961
This is primarily due to the low proliferation of the clonal B cells, which precludes conventional karyotyping in many cases. Translocations involving the immunoglobulin heavy chain (IGH) gene at 14q32 are characteristic of many B-cell lymphomas and myelomas. ...To clarify …
This is primarily due to the low proliferation of the clonal B cells, which precludes conventional karyotyping in many cases. Translocations …
Highly sensitive MYD88L265P mutation detection by droplet digital polymerase chain reaction in Waldenström macroglobulinemia.
Drandi D, Genuardi E, Dogliotti I, Ferrante M, Jiménez C, Guerrini F, Schirico ML, Mantoan B, Muccio V, Lia G, Zaccaria GM, Omedè P, Passera R, Orsucci L, Benevolo G, Cavallo F, Galimberti S, Sanz RG, Boccadoro M, Ladetto M, Ferrero S. Drandi D, et al. Haematologica. 2018 Jun;103(6):1029-1037. doi: 10.3324/haematol.2017.186528. Epub 2018 Mar 22. Haematologica. 2018. PMID: 29567768 Free PMC article.
One hundred and twenty-two of 128 (95.3%) bone marrow and 47/66 (71.2%) baseline peripheral blood samples scored positive for MYD88(L265P) To investigate whether MYD88(L265P) detection by droplet digital polymerase chain reaction could be used for minimal residual disease monitor …
One hundred and twenty-two of 128 (95.3%) bone marrow and 47/66 (71.2%) baseline peripheral blood samples scored positive for MYD88(L265P) T …
[Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis].
Takarada A, Momose H, Kurita N, Matsuoka R, Nakamura N, Sakamoto T, Kato T, Hattori K, Suehara Y, Yokoyama Y, Nishikii H, Maruyama Y, Obara N, Chiba S, Sakata-Yanagimoto M. Takarada A, et al. Rinsho Ketsueki. 2023;64(1):54-59. doi: 10.11406/rinketsu.64.54. Rinsho Ketsueki. 2023. PMID: 36775308 Japanese.
Genetic testing revealed that BM cells were positive for MYD88 mutation and positive for IgH rearrangement, whereas neither JAK2 nor CALR mutation was positive. ...
Genetic testing revealed that BM cells were positive for MYD88 mutation and positive for IgH rearrangement, whereas neither JAK2 nor …
Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute - Waldenström Macroglobulinemia 1.
Chitta KS, Paulus A, Ailawadhi S, Foster BA, Moser MT, Starostik P, Masood A, Sher T, Miller KC, Iancu DM, Conroy J, Nowak NJ, Sait SN, Personett DA, Coleman M, Furman RR, Martin P, Ansell SM, Lee K, Chanan-Khan AA. Chitta KS, et al. Leuk Lymphoma. 2013 Feb;54(2):387-96. doi: 10.3109/10428194.2012.713481. Epub 2012 Aug 27. Leuk Lymphoma. 2013. PMID: 22812491 Free PMC article.
The cell line has a modal chromosomal number of 46 and harbors chromosomal changes such as deletion of 6q21, monoallelic deletion of 9p21 (CDKN2A), 13q14 (RB1) and 18q21 (BCL-2), with a consistent amplification of 14q32 (immunoglobulin heavy chain; IgH) identical to its fo …
The cell line has a modal chromosomal number of 46 and harbors chromosomal changes such as deletion of 6q21, monoallelic deletion of 9p21 (C …
32 results